High-resolution Quantification of Specific mRNA Levels in Human Brain Autopsies and Biopsies
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چکیده
منابع مشابه
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Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA.
The general view that mRNA does not contain inosine has been challenged by the discovery of adenosine deaminases that act on RNA (ADARs). Although inosine monophosphate (IMP) cannot be detected in crude preparations of nucleotides derived from poly(A)+ RNA, here we show it is readily detectable and quantifiable once it is purified away from the Watson-Crick nucleotides. We report that IMP is pr...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2000
ISSN: 1088-9051
DOI: 10.1101/gr.10.8.1219